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Live longer with reduced calorie intake – healing practice



Extend lifespan by reducing calories

Scientific studies have shown that a strict calorie reduction the Life expectancy of animals may be prolonged. A new study now shows that even moderate calorie restriction helps people has relevant effects that could also affect life expectancy.

Reduced calorie intake has been shown to improve health and longevity in laboratory animals, and recent research indicates that these benefits may also extend to humans. The new findings are published in the specialist journal “immunityreported.

Inflammation is reduced

According to a recent Message Researchers from Yale University in the US show in the new study that moderate calorie restriction in people reduces the production of a protein called SPARC. This curbs harmful inflammation and improves the health of aging people.

The study conducted by Vishwa Deep Dixitdirector of the Yale Center for Research on Aging, follows a publication published earlier this year studywho identified the major health benefits of moderate caloric intake in humans.

In the new study, Dixit and its co-authors have analyzed additional data from the CLINICAL CALIERY study (understanding assessment of long-term effects of reducing of Energy), in which some participants calorie intake reduced by 14 percent for two years while others ate as usual.

The researchers then tracked the long-term health effects. In particular, the scientists analyzed experimental data to identify the molecules responsible for the positive effects of calorie reduction and the targets of a therapeutic treatment could be.

Improved metabolism

When they looked for genetic changes in subjects’ fat tissue after one and two years, they found that those who ate fewer calories had reduced amounts of a protein called SPARC which is linked to obesity, diabetes and inflammation.

They then examined the effects of the protein on the immune cells and had the health of mice.

The researchers found that SPARC triggers inflammation by targeting anti-inflammatory immune cells called macrophagesin a pro-inflammatory state.

However, reducing SPARC production by fat cells in mice reduced inflammation, improved blood pressure metabolism and extended their lifespan as they aged.

The findings could lead to preventive measures against age-related health decline, according to the director of the Yale Center for Research on Aging. “We now have a better understanding of how SPARC affects inflammation and lifespan by acting on macrophages”adds Said added. (ad)

Author and source information

This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been verified by health professionals.


  • Yale University: Cutting calories reduces protein linked to the aging process, (accessed August 15, 2022), Yale University
  • Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim Artyomov, Akiko Iwasaki, Andrew Wang, Vishwa Deep Dixit: the SPARC matrix protein induces an inflammatory response to interferon in macrophages during aging; in: Immunity, (published: 08/12/2022), immunity
  • Timothy W Rhoads & Rozalyn M Anderson: Calorie restriction has a new player; in: Science, (published on: 02/10/2022), Science

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot substitute a visit to the doctor.

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