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Which vaccine combinations are most effective – Heilpraxis



Corona: all approved vaccination programs in this country compared

It is currently hoped that soon adjusted vaccines against the disease caused by the coronavirus SARS-CoV-2 COVID-19[feminine] to be allowed. Until then, vaccination will continue with currently approved vaccines. In one study, the Effect those allowed in that country vaccine combinations compared.

For the first time, researchers have directly compared the vaccination effects of the five approved corona vaccination programs in Germany. Their results, which have already attracted media attention as a preprint, have now been published in the journal “Nature Communication“published.

Observations from a previous study confirmed

Professor of Transplantation and Immunology of Infections Martina Sester, together with a research team from the Saarland University Medical Campus in Homburg, studied the vaccine effects of so-called “homolog” vaccines (Biontech-Biontech, Moderna -Moderna, AstraZeneca- AstraZeneca) on the one hand and on the other hand recognized “heterologists” vaccination programs (AstraZeneca-Biontech, AstraZeneca-Moderna) compared.

We were able to confirm our observations from a previous study that the Astra double vaccination has the lowest immunogenicity; With the other combinations we can see very impressively that the variants with Moderna induce a stronger immune response than the respective combinations with Biontech‘ Sester explains in a Message.

“This is consistent with efficacy data on vaccine effects, but is also associated with slightly more side effects with Moderna combinations.”the scientist summarizes the central observations of this study.

Different effect of combination vaccines

In short, the heterologous combination of AstraZeneca and Moderna has the clearest immune response constructed, followed by the heterologous AstraZeneca-Biontech combination. Next is the Moderna double vaccination, which is somewhat superior to that of Biontech.

According to experts, the homologous combination of a double vaccination AstraZeneca has reached the weakest effect of the five compared.

According to the information, the data of a total of about 550 healthy people were included in the surveys, so the validity of the data is very valid. Knowledge of the different effects of vaccine combinations could also be used to optimize the vaccine reactions be relevant through follow-up vaccinations in high-risk patients. (ad)

Author and source information

This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been verified by health professionals.


  • Saarland University: Nature Communications: A study compares all approved vaccination programs in Germany for the first time (Accessed: August 14, 2022), Saarland University
  • Verena Klemis, Tina Schmidt, David Schub, Janine Mihm, Stefanie Marx, Amina Abu-Omar, Laura Ziegler, Franziska Hielscher, Candida Guckelmus, Rebecca Urschel, Stefan Wagenpfeil, Sophie Schneitler, Sören L. Becker, Barbara C. Gärtner, Urban Sester & Martina Sester: Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19 priming and BNT162b2 or mRNA-1273 with homologous COVID-19 vaccine regimens; in: Nature Communications, (published: 08/11/2022), Nature Communication

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot substitute a visit to the doctor.