New method detects pathogenic gut microbes
There is already plenty of evidence that intestinal bacteria to origin of many inflammatory diseases involved. An American research team has now developed a method to identify these pathogenic intestinal microbes. This opens the door to new approaches in obesity, liver disease, inflammatory bowel disease, cancer and certain neurological diseases.
researchers of Cedars-Sinai Medical Center and National Institute of Allergy and Infectious Diseases have developed a new method to identify intestinal bacteria implicated in the development of inflammatory diseases. The research results were recently published in the renowned journal “Science Translational Medicine” present.
When intestinal bacteria cross the intestinal barrier
The researchers used a protein found in the blood that can be used to identify gut microbes that have managed to cross the intestinal barrier. Gut bacteria leaving the gut can activate immune cells throughout the body, causing inflammatory reactions be mentioned.
Gut bacteria provide immune responses outside the gut
Thanks to the new method, it is now possible for the first time to identify such bacteria. Knowledge of the microbes involved provides the basis for therapeutic approaches to combat chronic inflammation.
“Microbes that cross the intestinal barrier typically cause inflammation and immune system activation, which are hallmarks of many inflammatory diseases.”confirms the study’s lead author Dr Ivan Vujkovic-Cvijin.
“By understanding which specific microbes cross the gut and cause inflammation in a disease, we can develop methods to get rid of those microbes and stop the disease.”concludes the scientist.
Currently, there is virtually no possibility of identifying bacteria
It has long been suspected that the gut microbiome plays an important role in inflammatory diseases. When certain intestinal bacteria cross the intestinal barrier, in many cases it becomes one. overactivation of the immune system sets off.
However, as the working group points out, there are currently few tools to determine which gut bacteria are able to cross the gut barrier.
New method may understand immune responses to gut bacteria
Using human serum samples obtained from human blood plasma, the researchers were able to all immune reactions quantify caused by intestinal microbes. In this way, it was possible for the first time to detect immune reactions all intestinal bacteria traceable throughout the body.
As the research team points out, this knowledge allows us to better understand whether and which intestinal bacteria are involved in the development of a disease.
New insights into disease progression
“Bacteria can migrate from the gut to other tissues, with pleiotropic effects that we don’t yet fully understand”adds professor doctor Suzanne Devkota of the working group. For this reason, she says, new methods are needed to assess what is happening.
First successes of the new method
When using the new method, the researchers found several bacteria in people with chronic inflammatory bowel disease that attacked the immune system. Such immune reactions could not be detected in samples from healthy people.
In particular, intestinal bacteria of the Collinsella, Bifidobacterium, Lachnospiraceae and Ruminococcaceae type were responsible for damage to the immune system.
“Many of the bacteria we identified were not previously thought to be possible causative agents of this disease”clarified Vujkovic-Cvijin.
New therapeutic targets for many diseases
“This microbial activity is likely relevant to disease progression and could represent a viable therapeutic target”, summarizes the main author of the study. The team now plans to follow up on the observations to learn more about the links between gut bacteria and immune responses. (vb)
Author and source information
This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been verified by health professionals.
Graduate editor (FH) Volker Blasek
- Cedars-Sinai Medical Center: New Method Detects Gut Microbes That Activate Immune Cells (Published: 08/17/2022), www.eurekalert.org
- Ivan Vujkovic-Cvijin, Suzanne Devkota, et al. : The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces; in: Science Translational Medicine (2022), science.org
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot substitute a visit to the doctor.
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