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New rapid test to simplify diagnosis – Heilpraxis



Introducing a new rapid test for cancer and heart attacks

An international research team recently introduced a new rapid test before, intended to help general practitioners heart attacks and certain cancer to diagnose or monitor their evolution. The test is designed in such a way that no laboratory is required for the evaluation.

researchers of Max Delbrück Center for Molecular Medicine of the Helmholtz Association presented an easy-to-use rapid test called CrisprZyme, which aims to help doctors diagnose cancer and heart attacks. The research results were recently published in the renowned journal “Nature’s nanotechnology” present.

A rapid test for various diseases

At least since the corona pandemic, most people in this country are with what is called Rapid antigen tests got in touch. These tests are based on antibodies that can bind to fragments of viral proteins on a test strip, causing the strip to change color accordingly.

Make the most complex variant PCR tests are in which the genetic material must first be processed and multiplied, which makes it possible to obtain a more precise result. However, such tests must be carried out in laboratories, which is why the result is not immediately available.

What is CRISPR-based diagnostics?

At the so-called CRISPR-based diagnostics a similar principle is followed. Some enzymes detect bits of DNA or RNA. Similar to corona tests, a sample of blood or urine placed on a test strip can be used to look for traces of RNA sequences responsible for a Diseases Where infection are typical.

Until now, however, samples for the procedure had to be prepared under controlled conditions and with expensive equipment in a laboratory so that the signal was strong enough for the test strip to react to it.

New test provides lab-free results

A joint working group of the Max Delbrück Center for Molecular Medicine, Charité – Universitätsmedizin Berlin, Imperial College London and MIT Boston has now succeeded in developing a rapid test based on this technology, in which no sample preparation by a laboratory necessary is.

Monitor the progression of cancer or heart disease

GPs can use the test to disease course like cancer or heart attacks. According to the research team, the implementation is simple and can be carried out at room temperature.

For example, with the test detect acute heart attacks or certain types of Prostate cancer differentiate.

“The result can be read with the naked eye or on a sheet of paper”approved Dr Michel Kaminski of the Berlin Charity.

“If we make diagnostic tests simpler, doctors can do them right away in their office – without making new appointments for follow-up tests and blood work”added Dr Marthe Broto from Imperial College London.

The amount of biomarkers is displayed via a color scale

The new test even shows the amount of a biomarker via a color scale. This is possible thanks to what is called nanoenzymes. They are tiny synthetic materials that behave like enzymes.

As the researchers explain, these nanoenzymes amplify the test signal, making it easier to read on the test strip. Temperature control or preparation by a laboratory is completely eliminated.

“The method can tell us exactly how many biomarkers are present”underlines the main author of the study Professor Molly Stevens from Imperial College London.

“So not only does it help us diagnose, but we can also use it to monitor the progression of a disease over time and the response to treatment.”explains the teacher.

The test can be extended to other clinical pictures

According to the scientists, the medical potential of the test is considerable, in particular because it can also be used to other clinical pictures Can be considered. In further steps, the team now wants to make the test even faster and more user-friendly. In addition, the exact reliability with which the test detects various biomarkers remains to be validated. (vb)

Author and source information

This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been verified by health professionals.


Graduate editor (FH) Volker Blasek


  • Max Delbrück Center for Molecular Medicine: CRISPR-Based Rapid Tests for Heart Attacks and Cancer (Published: 08/18/2022),
  • Imperial College London: Cancers and heart disease could be diagnosed more easily with new rapid test (Published: 04.08.2022),
  • Broto et al. : Nanozyme-catalyzed CRISPR test for the detection without preamplification of non-coding RNAs; in Nature Nanotechnology (2022),

Important Note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot substitute a visit to the doctor.

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