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High Fat Diet Causes More Pain – Healing Practice



High-fat diets appear to increase pain sensitivity

A particular fatty acidwhich multiplies on a high fat diet is included, according to a recent study Neurons bind, so affected more sensitive to pain react or even causeless pain could feel.

researchers of University of Texas at Dallas (USA) discovered that a fatty acid called palmitic acid (palmitic acid) binds to a specific receptor on nerve cells. According to study results recently published in the renowned journal “Scientific reportswere presented, this process mimics a Nerve cell damage after and leads to inflammation.

Increased pain sensation due to saturated fatty acids

Research suggests that a high fat diet with a increased sensitivity to pain connected is. Pain sensations that arise in this way appear at the same time independently of any pre-existing injury or condition.

Change already after eight weeks

The research group made the discovery in mice that for eight weeks received a high-fat diet. A comparison group received a normal diet instead. The high-fat diet was designed to Not for the development of Overweight Where high blood sugar LEDs.

Same changes as in chronic pain

A comparison of the two groups showed that the mice on the high-fat diet developed a so-called “hyperalgesic priming” developed. It refers to neurological changes on nerve cells, which also occurs during the transition from acute to chronic pain to monitor.

As a result of this change, the mice developed a allodynia – a condition in which pain is triggered by stimuli not normally associated with pain, such as light touches.

“This study shows you can have pain without having diabetes or another condition or injury”confirms the author of the corresponding study Dr Michael Burton.

Western diet high in saturated fat

According to him, a high-fat diet for a short period of time is enough to develop these symptoms. He also points out that such a regime in the United States widespread is.

The Western diet is generally high in saturated fats, which have been shown to promote diseases such as obesity, diabetes and their associated diseases. According to the researchers, the discovered mechanism may partly explain why the consumption of saturated fat systemic inflammation may cause.

Neuronal damage due to palmitic acid

According to the working group, the changes will mainly concern triggered by palmitic acid. it’s about the most common saturated fatty acid In food.

“Food metabolites cause inflammation before pathology develops”Explain doctor burton. The diet itself is the decisive factor here neuronal damage publicized.

In a follow-up study, the team now wants to investigate why neurons change when palmitic acid binds. “If we can find a way to prevent the transition from acute pain to chronic pain, that could do a lot of good.”, summarizes the author of the study. (vb)

Author and source information

This text corresponds to the requirements of the specialized medical literature, medical guidelines and current studies and has been verified by health professionals.


Graduate editor (FH) Volker Blasek


  • University of Texas at Dallas: UTD Researchers Find High-Fat Diet May Cause Pain Sensitivity (Published: 11/11/2022),
  • Jessica A Tierney, Calvin D Uong, Melissa E Lenert, et al. : A high-fat diet causes mechanical allodynia in the absence of injury or diabetic pathology; in: Scientific reports (2022),

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot substitute a visit to the doctor.

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