Newly Discovered Proteins Involved in the Development of Almost All Cancers – Healing Practice

Breakthrough: New insights into how cancer develops

A German research team from Würzburg reports a Breakthrough in cancer research. The working group discovered a group of proteins that play a key role in almost all cancers should play. the said MYC proteins should open new doors in cancer research and treatment.

researchers of Julius Maximilian University of Würzburg found it special hollow spheres from MYC proteins uncontrolled growth and the altered metabolism of tumor cells conduct. In addition, proteins help tumors protect themselves from hide the immune system. The results of the study were recently published in the renowned journal “Nature” gifts.

A game changer for cancer research

It is a discovery that profound consequences on the cancer treatment and research may have: special proteins in cancer cells hollow spherewhich are specific sites in the genome by cancer cells to protect them. If this protective shield falls, kill the cancer cell. The scientists involved speak of a game changer for cancer research.

Under stress, MYC proteins form protective spheres

The work is about what is called MYC genes and their proteins. Like the team around Martin Eiler and Elmer’s Wolf from the Institute of Biochemistry and Molecular Biology of the Julius Maximilians University of Würzburg was able to demonstrate that MYC proteins rearrange themselves in the cell nucleus in a spectacular way when they stressful states are exhibited as is in growing tumors prevalence.

Thousands of these proteins then project together into hollow spheres to to protect sensitive sites in the genome. It protects exactly the places where two kinds of enzymes can collide. The two enzymes are, on the one hand, those which read DNA and on the other hand on the enzymes which duplicate DNA.

The hollow spheres prevent the enzymes from “collapse”.

As the working group explains, enzymes can be imagined as two express trains that run on only one track. Accordingly, this track is the DNA. Under stress conditions, the hollow protein spheres thus prevent these two “trains” from colliding, resulting in multiple DNA breaks and finally to cell death would drive.

A promising new target for cancer cells

“These observations revolutionize our understanding of why MYC proteins are so crucial for tumor cell growth”, confirms the director of research, Professor Dr. Eilers. In addition, the balls offer a promising novelty target. On the one hand, the formation of such spheres could be prevented by active principles and, on the other hand, such hollow spheres could be destroyed.

The search for active ingredients has already begun

The scientists involved have already founded a new company with the help of investors to search for active substances that could interfere with the newly discovered functions of MYC proteins. (vb)